Anti-Fibrotic Effects of <i>Calotropis procera</i> (Ait.) R.Br Roots Barks against Diethylnitrosamine-Induced Hepatic Fibrosis in Rats

Background: Liver diseases including chronic hepatitis, steatosis, fibrosis, cirrhosis and liver cancer are now a public health problem. In 2002, accounted for 27.63% of hepatobiliary in Burkina Faso. Africa more particularly Faso, the majority population (about 80%) uses medicinal plants their primary care. Calotropis procera (Ait.) R.Br (Apocynaceae) is plant used Faso treatment problems. This work aims to evaluate anti-fibrotic properties roots barks. Methods: The activity ethanolic extract barks was evaluated using diethylnitrosamine (DEN) induce fibrosis male Wistar rats. Serum biomarkers, alanine transaminase (ALT), aspartate (AST), alkaline phosphatase (ALP), Total protein, Albumin, Υ-Glutamyl transferase (GGT) were activities antioxidant enzymes (Superoxide dismutase catalase) as well level malonedialdehyde (MDA) that nitric oxide (NO) determined homogenate. Results: rats suffering from hepatic with leads significant restoration biomarkers function particular, AST, ALP, GGT, Albumin. also causes reduction oxidative stress through increase rate Superoxide (SOD) catalase accompanied by drop MDA NO suggesting anti-oxidant effect extract. Conclusion: results study show has properties.